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ALB / Serum Albumin

albumin

Albumin ALB) is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in the ALB gene on chromosome 4 result in various anomalous proteins. Albumin is a globular unglycosylated serum protein of molecular weight 65000. The human albumin gene is 16961 nucleotides long from the putative 'cap' site to the first poly(A) addition site. It is split into 15 exons which are symmetrically placed within the 3 domains that are thought to have arisen by triplication of a single primordial domain. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to give the secreted albumin.

Gene Name: albumin
Synonyms: ALB, Albumin (32 AA), Albumin (AA 34), Albumin, Growth-inhibiting protein 20, PRO1341, PRO0883, Serum albumin, PRO0903
Target Sequences: NM_000477 NP_000468.1 P02768

Publications (2)

1
Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor. Li L, Guo Q, Liu J, Zhang J, Yin Y, Dong D, Fu L, Xu J, Chen W. Toxins. 2016 8: (WB; Human) [Full Text Article] [PubMed:26805881] [PMC:PMC4728550]
2
SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Vähätupa M, Nättinen J, Jylhä A, Aapola U, Kataja M, Kööbi P, Järvinen TAH, Uusitalo H, Uusitalo-Järvinen H. Investigative ophthalmology & visual science. 2018 July;59:3294-3306. [Full Text Article] [PubMed:30025079]

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ALB / Serum Albumin (2)
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).