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ALDH1A1 / ALDH1
aldehyde dehydrogenase 1 family, member A1
ALDH1A1 / ALDH1 belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
| Gene Name: | aldehyde dehydrogenase 1 family, member A1 |
| Synonyms: | ALDH1A1, Acetaldehyde dehydrogenase 1, ALDH class 1, ALDC, Aldehyde dehydrogenase 1, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH 1, RALDH1, ALHDII, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1 |
| Target Sequences: | NM_000689 NP_000680.2 P00352 |
Publications (3)
1
Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling. Ming Luo, Li Shang, Michael D Brooks, Evelyn Jiagge, Yongyou Zhu, Johanna M Buschhaus, Sarah Conley, Melissa A Fath, April Davis, Elizabeth Gheordunescu, Yongfang Wang, Ramdane Harouaka, Ann Lozier, Daniel Triner, Sean McDermott, Sofia D Merajver, Gary D Luker, Douglas R Spitz, Max S Wicha. Cell metabolism. 2018 July;28:69-86.e6. [Full Text Article]
[PubMed:29972798]
[PMC:PMC6037414]
2
BRCA1 mutation influences progesterone response in human benign mammary organoids. Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E Clare, Seema A Khan, J Julie Kim. Breast cancer research : BCR. 2019 Nov;21:124. [Full Text Article]
[PubMed:31771627]
[PMC:PMC6878650]
Related Antibodies: LS-B10149.
3
Expanding the use of monoclonal antibody therapy of cancer by using ionising radiation to upregulate antibody targets. Wattenberg MM, Kwilas AR, Gameiro SR, Dicker AP, Hodge JW. British journal of cancer. 2014 Mar;110:1472-80. [Full Text Article]
[PubMed:24556625]
[PMC:PMC3960628]
Related Antibodies: LS-B2497.
☰ Filters
Products
Proteins
(14)
Type
Over-Expression Lysate
(2)
Recombinant
(12)
Target
ALDH1A1 / ALDH1
(14)
Application
SDS-PAGE
(1)
Publications
No
(14)
Tag
6His, N-terminus
(3)
GST
(2)
GST, N-terminus
(1)
His, N-Terminal
(1)
His,N-terminus
(1)
His-T7
(1)
His-T7, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(11)
Mouse
(2)
Source
293T Cells
(1)
E. coli
(7)
HEK 293 Cells
(2)
Wheat Germ Extract
(3)
Yeast
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(2)
E. coli
None
100 µg/$342; 500 µg/$641; 20 µg/$254
Yeast
6His, N-terminus
1 mg/$1,973; 100 µg/$570; 20 µg/$395
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
Myc-DDK (Flag)
54.7 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His,N-terminus
SDS-PAGE
The recombinant human ALDH1A1comprises 507 amino acids and has a predicted molecular mass of 41.5 kDa. It migrates as an approximately 45-50 kDa band in SDS-PAGE under reducing conditions.
50 µg/$441
HEK 293 Cells
Myc-DDK (Flag)
54.7 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
54.7 kDa
20 µg/$150
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.0 kDa
10 µg/$368; 50 µg/$504
E. coli
His-T7, N-terminus
39.0kDa
10 µg/$272; 50 µg/$387; 200 µg/$772; 100 µg/$620; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016
E. coli
His, N-Terminal
58kDa
10 µg/$345; 50 µg/$842; 200 µg/$1,480; 1 mg/$2,788; 5 mg/$5,881; 2 mg/$3,137
Wheat Germ Extract
GST
80.63 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST
81.3 kDa
10 µg/$479; 25 µg/$670
E. coli
His-T7
58.4 kDa
10 µg/$267; 50 µg/$357; 100 µg/$572; 200 µg/$712; 1 mg/$1,741; 500 µg/$1,313; 5 mg/$2,695; 2 mg/$1,920
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