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ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: aldehyde dehydrogenase 2 family (mitochondrial)
Synonyms: ALDH2, Acetaldehyde dehydrogenase 2, ALDH-E2, ALDH class 2, ALDHI, ALDM, Liver mitochondrial ALDH
Target Sequences: NM_000690 NP_000681.2 P05091

Publications (2)

1
Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Salabei JK, Gibb AA, Hill BG. Nature protocols. 2014 9:421-38. (ICC; Human) [Full Text Article] [PubMed:24457333] [PMC:PMC4063296]
2
Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity. Conklin DJ, Malovichko MV, Zeller I, Das TP, Krivokhizhina TV, Lynch BH, Lorkiewicz P, Agarwal A, Wickramasinghe N, Haberzettl P, Sithu SD, Shah J, O'Toole TE, Rai SN, Bhatnagar A, Srivastava S. Toxicological sciences : an official journal of the Society of Toxicology. 2017 August;158:263-274. [Full Text Article] [PubMed:28482051] [PMC:PMC5837482] Related Antibodies: LS-B7924.

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Proteins (9)
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ALDH2 (9)
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ALDH2 Protein
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E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245
ALDH2 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
ALDH2 Protein - Purified recombinant protein ALDH2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
54.4 kDa
20 µg/$1,107
ALDH2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ALDH2 Protein - 12.5% SDS-PAGE of human ALDH2 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.8 kDa
10 µg/$479; 25 µg/$670
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E. coli
His-S
16.1 kDa
10 µg/$246; 50 µg/$299; 100 µg/$352; 200 µg/$442; 1 mg/$1,242; 500 µg/$882; 5 mg/$2,097; 2 mg/$1,391
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293T Cells
Myc-DDK (Flag)
56.38 kDa
20 µg/$150
ALDH2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
56.38 kDa
100 µg/$494
ALDH2 Protein
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E. coli
His, N-Terminal
57 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).