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ALDH8A1 belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.
Gene Name: | aldehyde dehydrogenase 8 family, member A1 |
Synonyms: | ALDH8A1, ALDH12, Aldehyde dehydrogenase 12, DJ352A20.2 |
Target Sequences: | NM_022568 NP_072090.1 Q9H2A2 |
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