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ALK2 / ACVR1
activin A receptor, type I
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
| Gene Name: | activin A receptor, type I |
| Family/Subfamily: | Protein Kinase , Activin/TGFb |
| Synonyms: | ACVR1, Activin A receptor type I, Activin A receptor, type I, ACTR-I, ActRIA, ACVR1A, ALK2, Activin receptor-like kinase 2, Activin receptor type-1, ACTRI, ACVRLK2, ALK-2, Activin receptor type I, Actr1, FOP, Hydroxyalkyl-protein kinase, SKR1, TSRI, TSR-I, Tsk7L |
| Target Sequences: | NM_001105 NP_001096.1 Q04771 |
Publications (3)
1
Coco is a dual activity modulator of TGFß signaling. Deglincerti A, Haremaki T, Warmflash A, Sorre B, Brivanlou AH. Development (Cambridge, England). 2015 142:2678-85. (IP; Xenopus laevis)
[Full Text Article]
[PubMed:26116664]
[PMC:PMC4529031]
Related Antibodies: LS-B2010.
2
OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma. Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M Carcaboso, Rheal A Towner. Journal of translational medicine. 2020 November;18:424. [Full Text Article]
[PubMed:33168005]
[PMC:PMC7654606]
Related Antibodies: LS-B11761.
3
Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. PLoS genetics. 2013 Nov;9:e1003863. [Full Text Article]
[PubMed:24244176]
[PMC:PMC3828128]
Related Antibodies: LS-B6835.
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ALK2 / ACVR1
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(93)
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(2)
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(4)
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Low endotoxin level
(7)
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa496-509) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$440
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa80-129) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa80-129) (HRP) Antibody
Mouse, Goat, Guinea pig, Bovine, Pig, Horse, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
Neuroscience
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa138-170) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
Neuroscience
ALK2 / ACVR1 Goat anti-Human Polyclonal (aa147-161) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ALK2 / ACVR1 Mouse anti-Human Monoclonal (2E2C11) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
ALK2 / ACVR1 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$951
ALK2 / ACVR1 Mouse anti-Human Monoclonal (2D5) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa38-87) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
ALK2 / ACVR1 Rabbit anti-Mouse Polyclonal (aa137-166) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa6-34) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa20-125) Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µl/$460
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$460
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa132-162) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa85-123) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
HEK 293 Cells
Myc-DDK (Flag)
55 kDa
20 µg/$1,107
Human Cells
His-Human IgG1 Fc
Less than 1.0 EU/µg protein (determined by LAL method).
39.6 kDa
200 µg/$1,148
Human Cells
Human IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.5 kDa
200 µg/$1,148
Human Cells
Human IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40 kDa
200 µg/$1,148
Fast Shipping
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
ALK2 / ACVR1 Rabbit anti-Mouse Polyclonal (aa137-166) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa132-162) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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