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ALK3 / BMPR1A

bone morphogenetic protein receptor, type IA

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Gene Name: bone morphogenetic protein receptor, type IA
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: BMPR1A, 10q23del, ALK3, ALK-3, BMP type-1A receptor, BMPR-1A, CD292, CD292 antigen, Activin receptor-like kinase 3, ACVRLK3, SKR5
Target Sequences: NM_004329 NP_004320.2 P36894

Publications (5)

1
Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes. Pache G, Schfer C, Wiesemann S, Springer E, Liebau M, Reinhardt HC, August C, Pavenstdt H, Bek MJ. American journal of physiology. Renal physiology. 2006 291:F654-62. [PubMed:16622178]
2
Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Cell death & disease. 2012 3:e308. [PubMed:22573038] [PMC:PMC3366082]
3
A crucial role of bone morphogenetic protein signaling in the wound healing response in acute liver injury induced by carbon tetrachloride. Oumi N, Taniguchi KA, Kanai AM, Yasunaga M, Nakanishi T, Sato K. International journal of hepatology. 2012 2012:476820. [PubMed:22701178] [PMC:PMC3372049] Related Antibodies: LS-C97653.
4
Immunohistological localization of BMP-2, BMP-7, and their receptors in knee joints with focal cartilage lesions. Hagen Schmal, Alexander T Mehlhorn, Ingo H Pilz, David Dovi-Akue, Christina Kirchhoff, Norbert P Südkamp, Ulrike Gerlach, Christian Lohrmann, Philipp Niemeyer. TheScientificWorldJournal. 2012 January;2012:467892. [Full Text Article] [PubMed:22272175] [PMC:PMC3259605] Related Antibodies: LS-C4217.
5
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a beta -catenin-dependent manner. Yang Z, Hai B, Qin L, Ti X, Shangguan L, Zhao Y, Wiggins L, Liu Y, Feng JQ, Chang JY, Wang F, Liu F. Molecular and cellular biology. 2013 Dec;33:4732-44. [Full Text Article] [PubMed:24081330] [PMC:PMC3838012] Related Antibodies: LS-C97656.
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Products
Proteins (14)
Over-Expression Lysate (2)
Recombinant (12)
ALK3 / BMPR1A (14)
No (14)
Fc/6His,C-terminus (2)
Fc/His,C-terminus (1)
Fc-6His, C-terminus (2)
GST (1)
GST, N-terminus (2)
His,C-terminus (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (8)
Mouse (4)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (4)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (3)
Purified (2)
Low endotoxin level (6)
Select
Wheat Germ Extract
GST, N-terminus
35.75 kDa
10 µg/$479; 25 µg/$670
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.8 kDa
200 µg/$843
ALK3 / BMPR1A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ALK3 / BMPR1A Protein - Purified recombinant protein BMPR1A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
57.4 kDa
20 µg/$1,107
ALK3 / BMPR1A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
60.2 kDa
100 µg/$494
ALK3 / BMPR1A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
60.2 kDa
20 µg/$150
Select
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.2 kDa
10 µg/$248; 50 µg/$288
Select
HEK 293 Cells
Fc/His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42 kDa
200 µg/$843
Select
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.1 kDa
10 µg/$248; 50 µg/$317
ALK3 / BMPR1A Protein
Select
E. coli
His-SUMO
56.57 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ALK3 / BMPR1A Protein - Recombinant Bone Morphogenetic Protein Receptor 1A By SDS-PAGE
Select
E. coli
His-T7
18.0 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
ALK3 / BMPR1A Protein - 12.5% SDS-PAGE of human BMPR1A stained with Coomassie Blue
Select
Wheat Germ Extract
GST
84.26 kDa
2 µg/$439
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.1kD
10 µg/$248; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.2kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).