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Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export and is required for spermatogenesis.
Gene Name: | AlkB, Alkylation Repair Homolog 5 (E. Coli) |
Synonyms: | ALKBH5, ABH5, OFOXD, OFOXD1 |
Target Sequences: | AK000315 BAA91078.1 Q6P6C2 |
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