ALOX12 / 12 Lipoxygenase

arachidonate 12-lipoxygenase

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ALOX12 / 12 Lipoxygenase (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ALOX12 / 12 Lipoxygenase Protein (Recombinant His-T7) (aa352-656) - LS-G14519

Source:

E. coli

Tag:

His-T7

Molecular Weight:

38.4 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human ALOX12 / 12 Lipoxygenase Protein (Recombinant GST) (Full Length) - LS-G27427

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

102.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ALOX12 / 12 Lipoxygenase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64973

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.5 kDa

Price:

20 µg/$1,107

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Human ALOX12 / 12 Lipoxygenase Protein (Recombinant GST, N-terminus) (aa564-663) - LS-G57751

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ALOX12 / 12 Lipoxygenase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74568

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.5 kDa

Price:

20 µg/$150

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ALOX12 / 12 Lipoxygenase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123038

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.5 kDa

Price:

100 µg/$494

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