ALOX12B

Arachidonate 12-lipoxygenase, 12R Type

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ALOX12B (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human ALOX12B Protein (Recombinant His-T7, N-terminus) (Leu479-Ile701) - LS-G133294

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

29.6kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human ALOX12B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88531

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.2 kDa

Price:

20 µg/$150

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Human ALOX12B Protein (Recombinant GST, N-terminus) (aa171-261) - LS-G57753

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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ALOX12B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118754

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.2 kDa

Price:

100 µg/$494

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Mouse ALOX12B Protein (Recombinant) (Glu389-Ile701) - LS-G133676

Source:

E. coli

Tag:

None

Molecular Weight:

39.7kDa

Price:

10 µg/$270; 50 µg/$372; 200 µg/$742; 100 µg/$592; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966

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Human ALOX12B Protein (Recombinant GST) (Full Length) - LS-G27430

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.8 kDa

Price:

10 µg/$479; 25 µg/$670

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