ALOX5 / 5-LOX

arachidonate 5-lipoxygenase

ALOX5 / 5-LOX is a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

ALOX5 / 5-LOX (8)

Publications

No (8)

Tag

GST (1)

His (2)

His, N-Terminal (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ALOX5 / 5-LOX Protein (Recombinant His, N-Terminal) (aa461-671) - LS-G13698

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

25.9 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Mouse ALOX5 / 5-LOX Protein (Recombinant His) (aa223-410) - LS-G13696

Source:

E. coli

Tag:

His

Molecular Weight:

23.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse ALOX5 / 5-LOX Protein (Recombinant His) (aa374-536) - LS-G13699

Source:

E. coli

Tag:

His

Molecular Weight:

20.1 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ALOX5 / 5-LOX Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64975

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.8 kDa

Price:

20 µg/$1,107

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ALOX5 / 5-LOX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99119

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.8 kDa

Price:

100 µg/$710

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Human ALOX5 / 5-LOX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74570

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.8 kDa

Price:

20 µg/$215

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Rat ALOX5 / 5-LOX Protein (Recombinant His, N-Terminal) (Leu373-Leu535) - LS-G133056

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

20kDa

Price:

10 µg/$278; 50 µg/$422; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ALOX5 / 5-LOX Protein (Recombinant GST) (Full Length) - LS-G27428

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

104.4 kDa

Price:

10 µg/$479; 25 µg/$670

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