ALOXE3

Arachidonate Lipoxygenase 3

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

ALOXE3 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ALOXE3 Protein (Recombinant GST) (Full Length) - LS-G34857

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.9 kDa

Price:

2 µg/$439

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Human ALOXE3 Protein (Recombinant GST, N-terminus) (aa1-97) - LS-G63031

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ALOXE3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91532

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.4 kDa

Price:

20 µg/$215

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ALOXE3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110643

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.4 kDa

Price:

100 µg/$710

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