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Alpha-1-Antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Gene Name: | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
Synonyms: | SERPINA3, Alpha-1-antichymotrypsin, AACT, GIG25, Growth-inhibiting protein 25, GIG24, Serpin A3, Growth-inhibiting protein 24, a-1-ACT |
Target Sequences: | NM_001085 NP_001076.2 P01011 |
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