ALS2 / Alsin

amyotrophic lateral sclerosis 2 (juvenile)

ALS2 / Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Proteins (2)

Type

Recombinant (2)

Target

ALS2 / Alsin (2)

Publications

No (2)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

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Human ALS2 / Alsin Protein (Recombinant GST, N-terminus) (aa221-320) - LS-G62993

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ALS2 / Alsin Protein (Recombinant His, N-Terminal) - LS-G144775

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

42.4 kDa

Price:

50 µg/$419

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