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AML1 / RUNX1

runt-related transcription factor 1

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.

Gene Name:	runt-related transcription factor 1
Synonyms:	RUNX1, AMLCR1, Aml1 oncogene, AML1, AML1-EVI-1, CBF-alpha-2, CBFA2, Acute myeloid leukemia 1, EVI-1, PEBP2A2, PEA2-alpha B, AML1-EVI-1 fusion protein, Oncogene AML-1, PEBP2-alpha B, PEBP2aB
Target Sequences:	NM_001754 NP_001745.2 Q01196

Publications (7)

TNF-a signaling regulates RUNX1 function in endothelial cells. Hannah A B Whitmore, Dhanesh Amarnani, Michael O'Hare, Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Julien Pedron, John H Bushweller, Joseph F Arboleda-Velasquez, Leo A Kim. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 November; [Full Text Article] [PubMed:33135824] [PMC:PMC7821222] Related Antibodies: LS-B13948.

Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Santiago Delgado-Tirado, Dhanesh Amarnani, Guannan Zhao, Elizabeth J Rossin, Dean Eliott, John B Miller, Whitney A Greene, Leslie Ramos, Said Arevalo-Alquichire, David Leyton-Cifuentes, Lucia Gonzalez-Buendia, Daniela Isaacs-Bernal, Hannah A B Whitmore, Natalia Chmielewska, Brandon V Duffy, Eric Kim, Heuy-Ching Wang, Jose M Ruiz-Moreno, Leo A Kim, Joseph F Arboleda-Velasquez. Scientific reports. 2020 November;10:20554. [Full Text Article] [PubMed:33257736] [PMC:PMC7705016] Related Antibodies: LS-B13948.

Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer. Yujin Kim, Bo Bin Lee, Dongho Kim, Sangwon Um, Eun Yoon Cho, Joungho Han, Young Mog Shim, Duk-Hwan Kim. Journal of Clinical Medicine. 2020 June;9: [Full Text Article] [PubMed:32498288] [PMC:PMC7356912] Related Antibodies: LS-B5382.

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Michael O'Hare, Dhanesh Amarnani, Hannah A B Whitmore, Miranda An, Claudia Marino, Leslie Ramos, Santiago Delgado-Tirado, Xinyao Hu, Natalia Chmielewska, Anita Chandrahas, Antonia Fitzek, Fabian Heinrich, Stefan Steurer, Benjamin Ondruschka, Markus Glatzel, Susanne Krasemann, Diego Sepulveda-Falla, David Lagares, Julien Pedron, John H Bushweller, Paul Liu, Joseph F Arboleda-Velasquez, Leo A Kim. The American journal of pathology. 2021 Jul;;191:1193-1208. [Full Text Article] [PubMed:33894177] [PMC:PMC8059259] Related Antibodies: LS-B13948.

Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases. Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R Reynolds, Anthoula Lazaris, Peter Metrakos. Communications biology. 2021 Aug;4:950. [Full Text Article] [PubMed:34376784] [PMC:PMC8355374] Related Antibodies: LS-C353932.

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis. Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Dhanesh Amarnani, Daniela Isaacs-Bernal, Hannah Whitmore, Said Arevalo-Alquichire, David Leyton-Cifuentes, Jose M Ruiz-Moreno, Joseph F Arboleda-Velasquez, Leo A Kim. Ophthalmology science. 2022 September;2: [Full Text Article] [PubMed:36213726] [PMC:PMC9536424] Related Antibodies: LS-B13948.

The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases. Miran Rada, Nour Hassan, Anthoula Lazaris, Peter Metrakos. Frontiers in oncology. 2022 November;12:1004793. [Full Text Article] [PubMed:36330498] [PMC:PMC9623070] Related Antibodies: LS-C353932.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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