Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
AML1 / RUNX1
runt-related transcription factor 1
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.
| Gene Name: | runt-related transcription factor 1 |
| Synonyms: | RUNX1, AMLCR1, Aml1 oncogene, AML1, AML1-EVI-1, CBF-alpha-2, CBFA2, Acute myeloid leukemia 1, EVI-1, PEBP2A2, PEA2-alpha B, AML1-EVI-1 fusion protein, Oncogene AML-1, PEBP2-alpha B, PEBP2aB |
| Target Sequences: | NM_001754 NP_001745.2 Q01196 |
Publications (7)
1
TNF-a signaling regulates RUNX1 function in endothelial cells. Hannah A B Whitmore, Dhanesh Amarnani, Michael O'Hare, Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Julien Pedron, John H Bushweller, Joseph F Arboleda-Velasquez, Leo A Kim. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 November; [Full Text Article]
[PubMed:33135824]
[PMC:PMC7821222]
Related Antibodies: LS-B13948.
2
Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Santiago Delgado-Tirado, Dhanesh Amarnani, Guannan Zhao, Elizabeth J Rossin, Dean Eliott, John B Miller, Whitney A Greene, Leslie Ramos, Said Arevalo-Alquichire, David Leyton-Cifuentes, Lucia Gonzalez-Buendia, Daniela Isaacs-Bernal, Hannah A B Whitmore, Natalia Chmielewska, Brandon V Duffy, Eric Kim, Heuy-Ching Wang, Jose M Ruiz-Moreno, Leo A Kim, Joseph F Arboleda-Velasquez. Scientific reports. 2020 November;10:20554. [Full Text Article]
[PubMed:33257736]
[PMC:PMC7705016]
Related Antibodies: LS-B13948.
3
Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer. Yujin Kim, Bo Bin Lee, Dongho Kim, Sangwon Um, Eun Yoon Cho, Joungho Han, Young Mog Shim, Duk-Hwan Kim. Journal of Clinical Medicine. 2020 June;9: [Full Text Article]
[PubMed:32498288]
[PMC:PMC7356912]
Related Antibodies: LS-B5382.
☰ Filters
Products
ELISA Kits
(8)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
(3)
DNA Binding Phosphorylation
(2)
Sandwich
(2)
Target
AML1 / RUNX1
(8)
Reactivity
Human
(6)
Mouse
(7)
Rat
(6)
Format
12 x 8-Well Microstrips
(2)
96-Well Microplate
(4)
96-Well Strip Plate
(2)
Publications
No
(8)
Sample Type
Adherent Cell Cultures
(4)
Cell Lysates
(2)
Nuclear Lysates
(2)
Plasma
(1)
Serum
(1)
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
1 Plate/$669
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Viewing 1-8
of 8
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
