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Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Gene Name: | angiomotin like 2 |
Synonyms: | AMOTL2, Angiomotin-like protein 2, Angiomotin like 2, LCCP, Leman coiled-coil protein, KIAA0989 |
Target Sequences: | NM_016201 NP_057285.3 Q9Y2J4 |
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