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AMOTL2

angiomotin like 2

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Gene Name:	angiomotin like 2
Synonyms:	AMOTL2, Angiomotin-like protein 2, Angiomotin like 2, LCCP, Leman coiled-coil protein, KIAA0989
Target Sequences:	NM_016201 NP_057285.3 Q9Y2J4

Publications (2)

IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment. Deborah Rotoli, Manuel Morales, María-Del-C Maeso, Julio Ávila, Natalia D Pérez-Rodríguez, Ali Mobasheri, Cornelis J F van Noorden, Pablo Martín-Vasallo. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2019 July;67:481-494. [Full Text Article] [PubMed:30794467] [PMC:PMC6598128] Related Antibodies: LS-C178611.

Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy. Rotoli D, Morales M, Ávila J, Maeso MDC, García MDP, Mobasheri A, Martín-Vasallo P. International journal of molecular sciences. 2017 18: (IHC; Human) [Full Text Article] [PubMed:28441737] [PMC:PMC5412470] Related Antibodies: LS-C178611.

Mouse AMOTL2 (Custom ELISA) ELISA Kit - LS-F19705

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Human AMOTL2 (Custom ELISA) ELISA Kit - LS-F19706

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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