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AMTN

amelotin

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).

Gene Name: amelotin
Synonyms: AMTN, Amelotin, RSTI689, UNQ689
Target Sequences: NM_212557 NP_997722.1 Q6UX39

Publications (1)

1
Amelotin is expressed in retinal pigment epithelium and localizes to hydroxyapatite deposits in dry age-related macular degeneration. Dinusha Rajapakse, Katherine Peterson, Sanghamitra Mishra, Jianguo Fan, Joshua Lerner, Maria Campos, Graeme Wistow. Translational research : the journal of laboratory and clinical medicine. 2020 May;219:45-62. [Full Text Article] [PubMed:32160961] [PMC:PMC7197213] Related Antibodies: LS-C799006, LS-C319460.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
AMTN (4)
No (4)
GST (1)
His (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
AMTN Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
AMTN Protein - 12.5% SDS-PAGE of human AMTN stained with Coomassie Blue
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Wheat Germ Extract
GST
48 kDa
10 µg/$479; 25 µg/$670
AMTN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
21.4 kDa
20 µg/$150
AMTN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21.4 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).