Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Gene Name: | angiogenin, ribonuclease, RNase A family, 5 |
Synonyms: | ANG, Angiogenin, HEL168, ALS9, Ribonuclease 5, RNASE5, Epididymis luminal protein 168, RNase 5 |
Target Sequences: | NM_001145 NP_001136.1 P03950 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.