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Angiogenin / ANG

angiogenin, ribonuclease, RNase A family, 5

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

Gene Name: angiogenin, ribonuclease, RNase A family, 5
Synonyms: ANG, Angiogenin, HEL168, ALS9, Ribonuclease 5, RNASE5, Epididymis luminal protein 168, RNase 5
Target Sequences: NM_001145 NP_001136.1 P03950

Publications (2)

1
Differential gene expression in normal esophagus and Barrett's esophagus. Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, Shaheen NJ, Chen X. Journal of gastroenterology. 2009 44:897-911. (IHC-P; Human) [PubMed:19468668]
2
Prostate cancer-derived angiogenin stimulates the invasion of prostate fibroblasts. Jones ML, Ewing CM, Isaacsa WB, Getzenberg RH. Journal of cellular and molecular medicine. 2012 16:193-201. (WB; Human) [Full Text Article] [PubMed:21352472] Related Antibodies: LS-C34969.

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Antibodies (91)
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Angiogenin / ANG (164)
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Angiogenin / ANG Antibody - Anti-Angiogenin / ANG antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
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Angiogenin / ANG Goat anti-Human Polyclonal Antibody
Human
ELISA, Neut, WB
Unconjugated
100 µg/$832
Angiogenin / ANG ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Angiogenin / ANG Protein - Recombinant Angiogenin By SDS-PAGE
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E. coli
6His, N-terminus
15.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
Angiogenin / ANG Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Angiogenin / ANG Antibody - Western blot of recombinant Angiogenin / ANG.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Angiogenin / ANG Rabbit anti-Mouse Polyclonal (aa25-145) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
Angiogenin / ANG ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
Angiogenin / ANG Protein
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E. coli
6His, N-terminus
14 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Angiogenin / ANG Protein - Recombinant Angiogenin By SDS-PAGE
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E. coli
6His, N-terminus
15.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$677; 200 µg/$845; 1 mg/$1,938; 500 µg/$1,485; 5 mg/$2,955; 2 mg/$2,124
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Angiogenin / ANG Rabbit anti-Bovine Polyclonal (HRP) Antibody
Bovine
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Angiogenin / ANG ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$565
Angiogenin / ANG ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
Angiogenin / ANG Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using ANG Antibody at dilution of 1:100
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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Angiogenin / ANG Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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Angiogenin / ANG Rabbit anti-Human Polyclonal (aa27-147) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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Angiogenin / ANG Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
Angiogenin / ANG Antibody - Immunohistochemical analysis of ANG staining in human liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Angiogenin / ANG Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
Angiogenin / ANG Antibody - Immunohistochemistry (IHC) analysis of ANG antibody in paraffin-embedded human rectum carcinoma tissue at 1:50, showing cell membrane and secreted staining. Negative control (the right) using PBS instead of primary antibody. Secondary antibody is Goat Anti-Rabbit.
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Angiogenin / ANG Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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Angiogenin / ANG Mouse anti-Human Monoclonal (Preservative Free) (5B12-F10-E7) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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Angiogenin / ANG Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (5B12-F10-E7) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
Angiogenin / ANG Antibody - Western Blot analysis of ANG expression in transfected 293T cell line by ANG monoclonal antibody (M05), clone 2A7.Lane 1: ANG transfected lysate(16.6 KDa).Lane 2: Non-transfected lysate.
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Angiogenin / ANG Mouse anti-Human Monoclonal (2A7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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Angiogenin / ANG Mouse Monoclonal (MANG-1) Antibody
Human
IHC, IHC-P
Unconjugated
150 µg/$728
Angiogenin / ANG Antibody - Western Blot analysis of extracts from 293T, Hela, 823 cells using ANG Antibody.
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Angiogenin / ANG Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 164 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).