ANGPT1 / Angiopoietin-1

angiopoietin 1

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

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Products

ELISA Kits (36)

Type

Competitive EIA (2)

Custom (4)

Sandwich (29)

Sandwich CLIA (1)

Target

ANGPT1 / Angiopoietin-1 (36)

Reactivity

Human (11)

Mouse (7)

Rat (8)

Bovine (3)

Dog (2)

Pig (3)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (13)

96-Well Strip Plate (22)

Publications

No (34)

Yes (2)

Sample Type

Breast Milk (1)

Cell Culture Supernatants (12)

Cell Lysates (5)

Cell Supernatant (1)

Plasma (32)

Saliva (1)

Serum (32)

Tissue Homogenates (12)

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F2956

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$632

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Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F10827

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

6.25 - 400 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$585

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F13065

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F5441

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F21304

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$528

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Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F5442

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

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Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F3958

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.234 - 15 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$610

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Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F3859

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.41 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

Select

Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F423

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

30 - 18000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Bovine ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F6220

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$779

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Rabbit ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F50066

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rabbit

Range:

0.1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$559

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Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F675

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

157 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$534

Select

Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F2576

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Breast Milk, Cell Culture Supernatants, Plasma, Saliva, Serum

Price:

1 Plate/$699

Select

Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F2955

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Bovine ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F10329

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Bovine

Range:

12.5 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$744

Select

Dog ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F7771

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Dog

Range:

2.34 - 150 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$748

Select

Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F10188

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$744

Select

Human ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F10826

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

46.88 - 3000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

Select

Bovine ANGPT1 / Angiopoietin-1 (Custom ELISA) ELISA Kit - LS-F13525

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Pig ANGPT1 / Angiopoietin-1 (Custom ELISA) ELISA Kit - LS-F13526

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Dog ANGPT1 / Angiopoietin-1 (Custom ELISA) ELISA Kit - LS-F13527

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Pig ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F32154

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F31477

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Rat ANGPT1 / Angiopoietin-1 (Sandwich ELISA) ELISA Kit - LS-F31513

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Bovine ANGPT1 / Angiopoietin-1 (Custom ELISA) ELISA Kit - LS-F50124

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Bovine

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$823

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