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ANKS1B is a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene.
Gene Name: | Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1B |
Synonyms: | ANKS1B, AIDA-1, Cajalin-2, Cajalin 2, EB1, E2A-PBX1-associated protein, EB-1, ANKS2 |
Target Sequences: | NM_020140 NP_064525.1 Q7Z6G8 |
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