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Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.
Gene Name: | chromosome 9 open reading frame 3 |
Synonyms: | C9orf3, Aminopeptidase O, AOPEP, C90RF3, ONPEP, AP-O, APO |
Target Sequences: | NM_032823 NP_116212.3 Q8N6M6 |
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