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AP3B1
adaptor-related protein complex 3, beta 1 subunit
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
| Gene Name: | adaptor-related protein complex 3, beta 1 subunit |
| Synonyms: | AP3B1, ADTB3A, AP-3 complex beta-3A subunit, Ap-3 complex beta3a subunit, Beta-3A-adaptin, Beta3A-adaptin, ADTB3, HPS2, HPS, PE, AP-3 complex subunit beta-1 |
| Target Sequences: | NM_003664 NP_003655.3 O00203 |
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