APBB1 / FE65

amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

APBB1 / FE65 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (2)

His, N-Terminal (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (2)

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Human APBB1 / FE65 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G57777

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APBB1 / FE65 Protein (Recombinant GST, N-terminus) (aa605-708) - LS-G57778

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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APBB1 / FE65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99351

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.1 kDa

Price:

100 µg/$494

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APBB1 / FE65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106613

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.8 kDa

Price:

100 µg/$494

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Human APBB1 / FE65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75902

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.1 kDa

Price:

20 µg/$150

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Human APBB1 / FE65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75903

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.8 kDa

Price:

20 µg/$150

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Human APBB1 / FE65 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65618

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.1 kDa

Price:

20 µg/$1,107

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Human APBB1 / FE65 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65620

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.8 kDa

Price:

20 µg/$1,107

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Human APBB1 / FE65 Protein (Recombinant His, N-Terminal) (Gly267-Phe528) - LS-G133102

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.0kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human APBB1 / FE65 Protein (Recombinant GST) (Full Length) - LS-G27473

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

103.4 kDa

Price:

10 µg/$479; 25 µg/$670

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