APEX2

APEX nuclease (apurinic/apyrimidinic endonuclease) 2

Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

APEX2 (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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Human APEX2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69792

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

20 µg/$1,107

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Human APEX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85551

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

20 µg/$150

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APEX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113908

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

100 µg/$494

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