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Apg7 / ATG7
autophagy related 7
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
| Gene Name: | autophagy related 7 |
| Synonyms: | ATG7, Apg7, APG7L, APG7-LIKE, Autophagy related 7, Autophagy-related protein 7, HAGP7, GSA7 |
| Target Sequences: | NM_006395 NP_006386.1 O95352 |
Publications (3)
1
Temporal orchestration of circadian autophagy rhythm by C/EBP. Ma D, Panda S, Lin JD. The EMBO journal. 2011 30:4642-51.
[PubMed:21897364]
[PMC:PMC3243590]
Related Antibodies: LS-C156616.
2
Autophagy-Related Gene 7 Polymorphisms and Cerebral Palsy in Chinese Infants. Xia L, Xu J, Song J, Xu Y, Zhang B, Gao C, Zhu D, Zhou C, Bi D, Wang Y, Zhang X, Shang Q, Qiao Y, Wang X, Xing Q, Zhu C. Frontiers in cellular neuroscience. 2019 November;13: [Full Text Article]
[PubMed:31749688]
[PMC:PMC6848160]
3
Autophagy mediates HIF2 alpha degradation and suppresses renal tumorigenesis. Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E. Oncogene. Jul; [Full Text Article]
[PubMed:24998849]
[PMC:PMC4286517]
Related Antibodies: LS-B330.
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Apg7 / ATG7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$515
Apg7 / ATG7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa284-313) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Apg7 / ATG7 Sheep anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
Apg7 / ATG7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$811
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa494-523) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Apg7 / ATG7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$565
Apg7 / ATG7 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$545
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Apg7 / ATG7 Rabbit anti-Human Polyclonal (aa540-569) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Apg7 / ATG7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100 µg/$442
Apg7 / ATG7 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
IF, IHC, WB
Biotin Conjugated
100 µg/$477
Apg7 / ATG7 Rabbit anti-Human Polyclonal (PerCP) Antibody
Mouse, Rat, Human
IF, IHC, WB
PerCP Conjugated
100 µg/$479
Apg7 / ATG7 Rabbit anti-Human Polyclonal (RPE) Antibody
Mouse, Rat, Human
IF, IHC, WB
RPE Conjugated
100 µg/$477
Apg7 / ATG7 Rabbit anti-Human Polyclonal (Atto 390) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 390 Conjugated
100 µg/$480
Apg7 / ATG7 Rabbit anti-Human Polyclonal (Atto 488) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 488 Conjugated
100 µg/$479
Apg7 / ATG7 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Rat, Human
IF, IHC, WB
APC Conjugated
100 µg/$479
Apg7 / ATG7 Rabbit anti-Human Polyclonal (Atto 594) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 594 Conjugated
100 µg/$479
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