APH1A / APH-1

APH1A gamma secretase subunit

APH1A / APH-1 is a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

☰ Filters

Products

Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

APH1A / APH-1 (5)

Publications

No (5)

Tag

6His-SUMO, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Purification

Purified (1)

Select

Human APH1A / APH-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90217

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.8 kDa

Price:

20 µg/$150

Select

Human APH1A / APH-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90218

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.7 kDa

Price:

20 µg/$150

Select

APH1A / APH-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101371

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.7 kDa

Price:

100 µg/$494

Select

APH1A / APH-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120038

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.8 kDa

Price:

100 µg/$494

Select

Human APH1A / APH-1 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-247) - LS-G56048

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

100 µg/$1,801; 20 µg/$1,247

Viewing 1-5 of 5 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.