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The apolipoprotein B mRNA editing protein (APOBEC1) is involved in the production of apolipoprotein B (apoB-)48 from apoB-100. APOBEC1 gene spans 18 kb and contains 5 exons, all of which are translated. The use of an alternative splice acceptor results in an alternative form APOBEC1 mRNA, which misses exon 2 causing a frameshift that produces a novel 36-amino acid peptide in which only the first 6-amino acids are shared with APOBEC1. The exon 2-skipped form accounts for approximately 50% of mRNA in the adult small intestine and up to 90% of APOBEC1 mRNA in the developing gut. Exon 2-skipping may thus be a quantitatively important mechanism regulating the expression on APOBEC1 in the gastrointestinal tract.
Gene Name: | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 |
Synonyms: | APOBEC1, HEPR, APOBEC-1, BEDP, CDAR1 |
Target Sequences: | NM_001644 NP_001635.2 P41238 |
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