APOBEC3D

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

APOBEC3D (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human APOBEC3D Protein (Recombinant GST) (Full Length) - LS-G36584

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73 kDa

Price:

2 µg/$439

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Human APOBEC3D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93137

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.4 kDa

Price:

20 µg/$150

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APOBEC3D Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128949

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.4 kDa

Price:

100 µg/$494

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