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Apolipoprotein (apo) C-I gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A copy of the apo C-I gene, apo C-I', is located 4 kb downstream in the same orientation, on the same chromosome. However, apo C-I' gene has no detectable mRNA product in any tissue, suggesting that it may be a pseudogene. The apoC-I gene is 4653 bases long and the apo C-I' is 4387 base pairs, and each contains four exons and 3 introns. The differences between the two genes includes a change of the codon for Gln-2 of the signal peptide region of apo C-I', which introduces a translation stop signal. A major difference between the two sequences is also found in the second and third introns of the apoC-I' gene, which contains 7.5 instead of 9 copies of Alu family sequences.
Gene Name: | Apolipoprotein C-I |
Synonyms: | APOC1, Apo-c1, Apo-CI, Apo-CIB, ApoC-I, Apolipoprotein C-I, ApoC-IB, APOC1B, Apolipoprotein C1, Apolipoprotein CI |
Target Sequences: | NM_001645 NP_001636.1 P02654 |
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