APP / Beta Amyloid Precursor

amyloid beta (A4) precursor protein

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

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Products

Proteins (22)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (9)

Recombinant (12)

Target

APP / Beta Amyloid Precursor (22)

Publications

No (22)

Tag

Fc (1)

Fc, C-terminus (1)

GST (2)

His (3)

His, N-Terminal (3)

His,N-terminus + GST (1)

His-MBP (1)

Myc-DDK (Flag) (10)

Species

Human (15)

Mouse (3)

Source

293T Cells (4)

E. coli (6)

HEK 293 Cells (8)

Human (1)

Human Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (3)

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Mouse APP / Beta Amyloid Precursor Protein (Recombinant His) (aa18-286) - LS-G13256

Source:

E. coli

Tag:

His

Molecular Weight:

31.2 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse APP / Beta Amyloid Precursor Protein (Recombinant His, N-Terminal) (aa672-711) - LS-G13255

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

7.9 kDa

Price:

10 µg/$287; 50 µg/$482; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88037

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83 kDa

Price:

20 µg/$150

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Human APP / Beta Amyloid Precursor Protein (Recombinant His) - LS-G1738

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human APP / Beta Amyloid Precursor Protein (Recombinant Fc) (Met1-Leu669) - LS-G97166

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

101 kDa

Price:

50 µg/$854

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Human APP / Beta Amyloid Precursor Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70801

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.9 kDa

Price:

20 µg/$1,107

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Human APP / Beta Amyloid Precursor Protein (Recombinant His-MBP) (aa672-711) - LS-G13260

Source:

E. coli

Tag:

His-MBP

Molecular Weight:

50.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88033

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.94 kDa

Price:

20 µg/$215

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Human APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88034

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.55 kDa

Price:

20 µg/$150

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Human APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88035

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.9 kDa

Price:

20 µg/$215

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Human APP / Beta Amyloid Precursor Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Leu18-Ile699) - LS-G97006

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~77 kDa

Price:

200 µl/$283

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Human APP / Beta Amyloid Precursor Protein (Over-Expression Lysate His, N-Terminal) (Leu18-Ile699) - LS-G97010

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~77 kDa

Price:

100 µg/$298

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APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103183

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.9 kDa

Price:

100 µg/$710

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APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103182

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83 kDa

Price:

100 µg/$494

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Human APP / Beta Amyloid Precursor Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70799

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83 kDa

Price:

20 µg/$1,107

Select

APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125656

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.55 kDa

Price:

100 µg/$494

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Human APP / Beta Amyloid Precursor Protein (Recombinant Fc, C-terminus) - LS-G146025

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

94.6 kDa

Price:

10 µg/$377; 50 µg/$818

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APP / Beta Amyloid Precursor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123164

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.94 kDa

Price:

100 µg/$710

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Human APP / Beta Amyloid Precursor Protein (Recombinant His,N-terminus + GST) (Asp672-Val710) - LS-G138298

Source:

E. coli

Tag:

His,N-terminus + GST

Molecular Weight:

32.2 kDa

Price:

100 µg/$843

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Mouse APP / Beta Amyloid Precursor Protein (Recombinant His) (aa381-713) - LS-G140929

Source:

E. coli

Sequence Length:

332 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

36.63 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human APP / Beta Amyloid Precursor Protein (Recombinant GST) (Full Length) - LS-G27489

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

57.31 kDa

Price:

10 µg/$479; 25 µg/$670

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Human APP / Beta Amyloid Precursor Protein (Recombinant GST) (Full Length) - LS-G27490

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

59.29 kDa

Price:

2 µg/$439

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