Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | adenine phosphoribosyltransferase |
Synonyms: | APRT, AMP, AMP diphosphorylase, APRTD, AMP pyrophosphorylase, Transphosphoribosidase |
Target Sequences: | NM_000485 NP_000476.1 P07741 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.