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AQP2 / Aquaporin 2

aquaporin 2 (collecting duct)

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Gene Name: aquaporin 2 (collecting duct)
Family/Subfamily: Transporter , Aquaporin
Synonyms: AQP2, AQP-CD, ADH water channel, Aquaporin 2 (collecting duct), AQP-2, Aquaporin 2, Aquaporin-CD, Aquaporin-2, Water-channel aquaporin 2, WCH-CD
Target Sequences: NM_000486 NP_000477.1 P41181

Publications (9)

1
Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA. The Journal of biological chemistry. 2008 283:24617-27. [PubMed:18606813] [PMC:PMC2528999]
2
Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Moeller HB, Knepper MA, Fenton RA. Kidney international. 2009 75:295-303. [PubMed:18843259] [PMC:PMC3502047]
3
Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct. Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:2441-6. [PubMed:19190182] [PMC:PMC2650175]
4
Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear. Takumida M, Kakigi A, Egami N, Nishioka R, Anniko M. Acta oto-laryngologica. 2012 132:807-13. (ICC, IHC; Mouse) [PubMed:22768909]
5
Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus. Trimpert C, van den Berg DT, Fenton RA, Klussmann E, Deen PM. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:4389-97. (WB, DB; Dog) [PubMed:22778181]
6
Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. Toka HR, Al-Romaih K, Koshy JM, DiBartolo S, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR. Journal of the American Society of Nephrology : JASN. 2012 23:1879-90. [PubMed:22997254] [PMC:PMC3482734]
7
Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and rats--species differences and technical considerations. Nowik M, Kampik NB, Mihailova M, Eladari D, Wagner CA. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011 26:1059-72. (WB; Rat) [Full Text Article] [PubMed:21220937]
8
Aquaporin-2 plays an important role in water transportation through the bladder wall in rats. Yosuke Morizawa, Kazumasa Torimoto, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Akihide Hirayama, Nobumichi Tanaka, Kiyohide Fujimoto. Neurourology and urodynamics. 2018 November;37:2434-2440. [Full Text Article] [PubMed:29797427] Related Antibodies: LS-C312893.
9
Sodium plays an important role in the absorption of intravesical fluid. Yosuke Morizawa, Kazumasa Torimoto, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto. Lower urinary tract symptoms. 2021 Janurary;13:177-182. [Full Text Article] [PubMed:32410367] Related Antibodies: LS-C312893.
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ELISA Kits (26)
Competitive EIA (2)
Custom (3)
Sandwich (19)
Sandwich CLIA (2)
AQP2 / Aquaporin 2 (26)
Human (6)
Mouse (5)
Rat (6)
Chicken (1)
Dog (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (2)
Sheep (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (4)
96-Well Strip Plate (19)
No (26)
Cell Lysates (2)
Plasma (15)
Serum (15)
Tissue Homogenates (7)
Urine (2)
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP2 / Aquaporin 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
AQP2 / Aquaporin 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
AQP2 / Aquaporin 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$1,018
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates, Urine
1 Plate/$715
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).