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AQP4 / Aquaporin 4

aquaporin 4

AQP4, also known as Mercurial-insensitive water channel (MIWC), is the fourth member of the aquaporin water channel family. This osmoreceptor regulates body water balance and mediates water flow within the central nervous system. It appears to play some specific role in the functioning of skeletal muscles, retina, and auditory system. Contrary to other aquaporin family members, AQP4 is not inhibited by mercurial compounds. The expression of AQP4 is reduced in the skeletal muscles of Duchenne muscular dystrophy syndrome patients. In addition, a dysfunction of the AQP4 may contribute to the development of brain edema; some results indicate that interference with the subcellular localization of this protein may have a therapeutic potential for delaying the onset of this pathological condition.

Gene Name: aquaporin 4
Family/Subfamily: Transporter , Aquaporin
Synonyms: AQP4, Aquaporin type4, Aquaporin 4, Aquaporin-4, HMIWC2, MIWC, WCH4, AQP-4
Target Sequences: NM_001650 NP_001641.1 P55087

Publications (5)

1
Aquaporin pathways and mucin secretion of Bowman's glands might protect the olfactory mucosa. Solbu TT, Holen T. Chemical senses. 2012 37:35-46. (IHC; Rat) [Full Text Article] [PubMed:21745799] Related Antibodies: LS-C3805.
2
Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury. Li W, Tan C, Liu Y, Liu X, Wang X, Gui Y, Qin L, Deng F, Yu Z, Hu C, Chen L. Molecular medicine reports. 2015 November;12:7756-62. (Human) [Full Text Article] [PubMed:26458999] Related Antibodies: LS-C3805.
3
Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Daniel G Couch, Hollie Cook, Catherine Ortori, Dave Barrett, Jonathan N Lund, Saoirse E O'Sullivan. Inflammatory bowel diseases. 2019 May;25:1006-1018. [Full Text Article] [PubMed:31054246]
4
Effects of caffeic acid phenethyl ester in reducing cerebral edema in rat subjects experiencing brain injury: An in vivo study. Rizha Anshori Nasution, Andi Asadul Islam, Mochammad Hatta, Prihantono, Warsinggih, Dany H Ludong, Ismail, Harakati Wangi, Muh Nassrum Massi, Khairul Ihsan Nasution. Annals of medicine and surgery (2012). 2020 September;57:328-333. [Full Text Article] [PubMed:32874565] [PMC:PMC7452142]
5
Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic-ischemic brain injury. Jennifer K Lee, Dapeng Liu, Dengrong Jiang, Ewa Kulikowicz, Aylin Tekes, Peiying Liu, Qin Qin, Raymond C Koehler, Manisha Aggarwal, Jiangyang Zhang, Lee J Martin. The Journal of comparative neurology. 2021 July;529:2750-2770. [Full Text Article] [PubMed:33543493] [PMC:PMC8113130] Related Antibodies: LS-B11637, LS-C413484.
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Proteins (10)
Over-Expression Lysate (2)
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AQP4 / Aquaporin 4 (10)
No (10)
6His, N-terminus (2)
6His-Myc, C-terminus (1)
His (2)
His-GST (2)
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Myc-DDK (Flag) (2)
Human (6)
Mouse (3)
Rat (1)
293T Cells (1)
E. coli (5)
HEK 293 Cells (1)
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AQP4 / Aquaporin 4 Protein - Recombinant Aquaporin 4 By SDS-PAGE
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E. coli
His-GST
47.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
AQP4 / Aquaporin 4 Protein
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E. coli
His-SUMO
23.98 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
AQP4 / Aquaporin 4 Protein
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E. coli
His
15.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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E. coli
99 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
11 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
AQP4 / Aquaporin 4 Protein - Recombinant Aquaporin 4 By SDS-PAGE
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E. coli
His-GST
47.4 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
AQP4 / Aquaporin 4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
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293T Cells
Myc-DDK (Flag)
32.1 kDa
20 µg/$150
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HEK 293 Cells
Myc-DDK (Flag)
32.1 kDa
100 µg/$494
AQP4 / Aquaporin 4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
AQP4 / Aquaporin 4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.The reducing (R) protein migrates as 16 kDa in SDS-PAGE may be due to glycosylation.
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Yeast
6His-Myc, C-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).