AR / Androgen Receptor

androgen receptor

The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility. Androgen signaling through the androgen receptor (AR) appears to be involved in all aspects of prostate cancer, from initiation to development of treatment resistance. Gain-of-function AR gene mutations and/or altered signaling through AR have been suggested to contribute to disease progression. A recent study showed decreased expression of AR in response to incubation of LNCaP prostate carcinoma cells with PC-SPES, a mixture of eight herbs (Bonham et al. 2002). Two forms of AR that differ in their N termini have been isolated: AR A (87 kD), which is derived from translation of an internal methionine codon (met188), and AR B (110 kD). The two isoforms are expressed in similar tissues; however, AR B generally is the more abundant form.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

AR / Androgen Receptor (12)

Publications

No (12)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (2)

His-GST (1)

His-S (1)

Myc-DDK (Flag) (4)

Species

Human (8)

Mouse (1)

Rat (2)

Source

293T Cells (2)

E. coli (7)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human AR / Androgen Receptor Protein (Recombinant 6His, N-terminus) (Met1-Gln556) - LS-G26987

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

62 kDa

Price:

10 µg/$283; 50 µg/$355; 100 µg/$428

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Human AR / Androgen Receptor Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa551-919) - LS-G56096

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human AR / Androgen Receptor Protein (Recombinant GST, N-terminus) (aa221-320) - LS-G57794

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AR / Androgen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98893

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99 kDa

Price:

100 µg/$710

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Human AR / Androgen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74499

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99 kDa

Price:

20 µg/$215

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Mouse AR / Androgen Receptor Protein (Recombinant His-GST) (aa156-310) - LS-G13575

Source:

E. coli

Tag:

His-GST

Molecular Weight:

48.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human AR / Androgen Receptor Protein (Recombinant His-S) (aa15-246) - LS-G13571

Source:

E. coli

Tag:

His-S

Molecular Weight:

30.5 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Human AR / Androgen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74500

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

20 µg/$150

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AR / Androgen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121786

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

100 µg/$494

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Human AR / Androgen Receptor Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145266

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

72.5 kDa

Price:

50 µg/$419

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Rat AR / Androgen Receptor Protein (Recombinant His) (aa491-679) - LS-G13577

Source:

E. coli

Tag:

His

Molecular Weight:

22.5 kDa

Price:

10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430

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Rat AR / Androgen Receptor Protein (Recombinant His) (aa765-902) - LS-G13574

Source:

E. coli

Tag:

His

Molecular Weight:

17.5 kDa

Price:

10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430

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