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6737 Mowry Ave
Newark, CA 94560
United States
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ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
| Gene Name: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| Synonyms: | ARAP3, Centaurin-delta-3, CENTD3, DRAG1, Centaurin, delta 3, Cnt-d3 |
| Target Sequences: | NM_022481 NP_071926.4 Q8WWN8 |
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