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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
Gene Name: | apoptosis resistant E3 ubiquitin protein ligase 1 |
Synonyms: | AREL1, KIAA0317, Protein KIAA0317 |
Target Sequences: | AB002315 BAA20775.2 O15033 |
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