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ARF1

ADP-ribosylation factor 1

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Name: ADP-ribosylation factor 1
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARF1, ADP-ribosylation factor 1
Target Sequences: NM_001658 NP_001649.1 P84077

Publications (1)

1
p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. Luo W, Wang Y, Reiser G. The Journal of biological chemistry. 2007 282:30246-55. (WB) [PubMed:17693410]

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Proteins (16)
Over-Expression Lysate (9)
Recombinant (7)
ARF1 (16)
No (16)
10His-GST, N-terminus + Myc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (12)
Human (12)
293T Cells (5)
E. coli (2)
HEK 293 Cells (7)
Wheat Germ Extract (2)
Purified (3)
ARF1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ARF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
100 µg/$494
ARF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
100 µg/$494
ARF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
100 µg/$494
ARF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
100 µg/$494
ARF1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ARF1 Protein - 12.5% SDS-PAGE of human ARF1 stained with Coomassie Blue
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Wheat Germ Extract
GST
45.65 kDa
10 µg/$479; 25 µg/$670
ARF1 Protein - Purified recombinant protein ARF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$1,107
ARF1 Protein - Purified recombinant protein ARF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$1,107
ARF1 Protein - Purified recombinant protein ARF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$150
ARF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$150
ARF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.5 kDa
20 µg/$150
ARF1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-GST, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Viewing 1-16 of 16 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).