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ARF6

ADP-ribosylation factor 6

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Gene Name: ADP-ribosylation factor 6
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARF6, ADP-ribosylation factor 6
Target Sequences: NM_001663 NP_001654.1 P62330

Publications (1)

1
Eyes shut homolog (EYS) interacts with matriglycan of O-mannosyl glycans whose deficiency results in EYS mislocalization and degeneration of photoreceptors. Yu Liu , Miao Yu , Xuanze Shang, My Hong Hoai Nguyen, Shanmuganathan Balakrishnan, Rachel Sager, Huaiyu Hu. Scientific reports. 2020 May;10:7795. [Full Text Article] [PubMed:32385361] [PMC:PMC7210881] Related Antibodies: LS-B5846.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
ARF6 (6)
No (6)
GST (1)
His (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
ARF6 Protein - Purified recombinant protein ARF6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
19.9 kDa
20 µg/$1,107
ARF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
19.9 kDa
100 µg/$494
ARF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
19.9 kDa
20 µg/$150
ARF6 Protein
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E. coli
His-SUMO
36.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ARF6 Protein - 12.5% SDS-PAGE of human ARF6 stained with Coomassie Blue
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Wheat Germ Extract
GST
44.99 kDa
10 µg/$479; 25 µg/$670
ARF6 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).