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ARG1 / Arginase 1

arginase 1

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name:	arginase 1
Synonyms:	ARG1, Arginase, liver, Arginase 1, Liver-type arginase, Liver arginase, Arginase-1, Type I arginase
Target Sequences:	NM_000045 NP_000036.2 P05089

Publications (10)

Caffeine alters circadian rhythms and expression of disease and metabolic markers. Sherman H, Gutman R, Chapnik N, Meylan J, le Coutre J, Froy O. The international journal of biochemistry & cell biology. 2011 43:829-38. [PubMed:21352949]

All-trans retinoic acid modifies the expression of clock and disease marker genes. Sherman H, Gutman R, Chapnik N, Meylan J, le Coutre J, Froy O. The Journal of nutritional biochemistry. 2012 23:209-17. [PubMed:21497500]

Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia. Ryu JC, Davidson BP, Xie A, Qi Y, Zha D, Belcik JT, Caplan ES, Woda JM, Hedrick CC, Hanna RN, Lehman N, Zhao Y, Ting A, Lindner JR. Circulation. 2013 127:710-9. (IHC-P; Mouse) [Full Text Article] [PubMed:23307829] [PMC:PMC3573704] Related Antibodies: LS-B4789.

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. van Straten G, van Steenbeek FG, Grinwis GC, Favier RP, Kummeling A, van Gils IH, Fieten H, Groot Koerkamp MJ, Holstege FC, Rothuizen J, Spee B. PloS one. 2014 9:e100077. (IHC; Canine) [Full Text Article] [PubMed:24945279] [PMC:PMC4063766]

Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R. Circulation research. 2014 115:662-7. (WB; Bovine) [Full Text Article] [PubMed:25070003]

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis. Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F. Mucosal immunology. 2017 March;10:421-433. (Human) [Full Text Article] [PubMed:27301879] [PMC:PMC5159334] Related Antibodies: LS-B4789.

Myelin basic protein charge isomers change macrophage polarization. Tsitsilashvili E, Sepashvili M, Chikviladze M, Shanshiashvili L, Mikeladze D. Journal of inflammation research. 2019 January;12:25-33. [Full Text Article] [PubMed:30774410] [PMC:PMC6350649]

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models. Gravina GL, Mancini A, Mattei C, Vitale F, Marampon F, Colapietro A, Rossi G, Ventura L, Vetuschi A, Di Cesare E, Fox JA, Festuccia C. Oncotarget. 2017 May;8:29865-29886. [Full Text Article] [PubMed:28415741] [PMC:PMC5444710]

Appearance of Alveolar Macrophage Subpopulations in Correlation With Histopathological Effects in Short-Term Inhalation Studies With Biopersistent (Nano)Materials. Johanna Koltermann-Jülly, Lan Ma-Hock, Sibylle Gröters, Robert Landsiedel. Toxicologic pathology. 2020 April;48:446-464. [Full Text Article] [PubMed:32162596] Related Antibodies: LS-B4660.

rhBMP2 alone does not induce macrophage polarization towards an increased inflammatory response. Emily L Durham, Rajiv Kishinchand, Zachary J Grey, James J Cray. Molecular immunology. 2020 January;117:94-100. [Full Text Article] [PubMed:31759326] [PMC:PMC6931256]

Arginase Assay Kit (Colorimetric) - LS-K334

Type:

Detection/Quantition

Target:

ARG1 / Arginase 1

Application:

Spectrophotometry (visible)

Price:

100 Tests/$400

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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