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ARG1 / Arginase 1

arginase 1

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: arginase 1
Synonyms: ARG1, Arginase, liver, Arginase 1, Liver-type arginase, Liver arginase, Arginase-1, Type I arginase
Target Sequences: NM_000045 NP_000036.2 P05089

Publications (10)

1
Caffeine alters circadian rhythms and expression of disease and metabolic markers. Sherman H, Gutman R, Chapnik N, Meylan J, le Coutre J, Froy O. The international journal of biochemistry & cell biology. 2011 43:829-38. [PubMed:21352949]
2
All-trans retinoic acid modifies the expression of clock and disease marker genes. Sherman H, Gutman R, Chapnik N, Meylan J, le Coutre J, Froy O. The Journal of nutritional biochemistry. 2012 23:209-17. [PubMed:21497500]
3
Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia. Ryu JC, Davidson BP, Xie A, Qi Y, Zha D, Belcik JT, Caplan ES, Woda JM, Hedrick CC, Hanna RN, Lehman N, Zhao Y, Ting A, Lindner JR. Circulation. 2013 127:710-9. (IHC-P; Mouse) [Full Text Article] [PubMed:23307829] [PMC:PMC3573704] Related Antibodies: LS-B4789.
4
Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. van Straten G, van Steenbeek FG, Grinwis GC, Favier RP, Kummeling A, van Gils IH, Fieten H, Groot Koerkamp MJ, Holstege FC, Rothuizen J, Spee B. PloS one. 2014 9:e100077. (IHC; Canine) [Full Text Article] [PubMed:24945279] [PMC:PMC4063766]
5
Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R. Circulation research. 2014 115:662-7. (WB; Bovine) [Full Text Article] [PubMed:25070003]
6
The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis. Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F. Mucosal immunology. 2017 March;10:421-433. (Human) [Full Text Article] [PubMed:27301879] [PMC:PMC5159334] Related Antibodies: LS-B4789.
7
Myelin basic protein charge isomers change macrophage polarization. Tsitsilashvili E, Sepashvili M, Chikviladze M, Shanshiashvili L, Mikeladze D. Journal of inflammation research. 2019 January;12:25-33. [Full Text Article] [PubMed:30774410] [PMC:PMC6350649]
8
Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models. Gravina GL, Mancini A, Mattei C, Vitale F, Marampon F, Colapietro A, Rossi G, Ventura L, Vetuschi A, Di Cesare E, Fox JA, Festuccia C. Oncotarget. 2017 May;8:29865-29886. [Full Text Article] [PubMed:28415741] [PMC:PMC5444710]
9
Appearance of Alveolar Macrophage Subpopulations in Correlation With Histopathological Effects in Short-Term Inhalation Studies With Biopersistent (Nano)Materials. Johanna Koltermann-Jülly, Lan Ma-Hock, Sibylle Gröters, Robert Landsiedel. Toxicologic pathology. 2020 April;48:446-464. [Full Text Article] [PubMed:32162596] Related Antibodies: LS-B4660.
10
rhBMP2 alone does not induce macrophage polarization towards an increased inflammatory response. Emily L Durham, Rajiv Kishinchand, Zachary J Grey, James J Cray. Molecular immunology. 2020 January;117:94-100. [Full Text Article] [PubMed:31759326] [PMC:PMC6931256]
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Proteins (24)
Over-Expression Lysate (2)
Recombinant (22)
ARG1 / Arginase 1 (24)
No (24)
6His, C-terminus (4)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (5)
His, N-Terminal (4)
His, N-terminus (1)
His-Myc (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (16)
Mouse (5)
Rat (2)
293T Cells (1)
E. coli (15)
HEK 293 Cells (2)
Human Cells (3)
Mammalian Cells (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (10)
Low endotoxin level (8)
Biologically active (1)
ARG1 / Arginase 1 Protein - Recombinant Arginase By SDS-PAGE
Select
E. coli
His, N-Terminal
36.5 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
ARG1 / Arginase 1 Protein - Recombinant Arginase By SDS-PAGE
Select
E. coli
6His, N-terminus
36.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
ARG1 / Arginase 1 Protein
Select
Yeast
His
36.81 kD
100 µg/$499; 1 mg/$1,683; 20 µg/$364
ARG1 / Arginase 1 Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
Select
E. coli
His
36.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
ARG1 / Arginase 1 Protein - Active Arginase (ARG) by WB
Select
E. coli
His, N-Terminal
37kDa
10 µg/$333; 50 µg/$770; 200 µg/$1,388; 100 µg/$1,176; 1 mg/$2,677; 500 µg/$2,172; 5 mg/$5,377; 2 mg/$2,868
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.6kD
10 µg/$343; 50 µg/$651; 500 µg/$2,403; 1 mg/$3,431
ARG1 / Arginase 1 Protein - Purified recombinant protein ARG1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
34.6 kDa
20 µg/$1,107
Select
Human Cells
His-Myc
Less than 1.0 EU/µg protein (determined by LAL method).
36.7 kDa
50 µg/$1,070
ARG1 / Arginase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
34.6 kDa
20 µg/$150
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.8 kDa
10 µg/$344; 50 µg/$584
Select
E. coli
322 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
35.53 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
ARG1 / Arginase 1 Protein - Recombinant Human Arginase-1 Protein (His Tag)
Select
E. coli
His, N-terminus
36.9kDa
50 µg/$421; 100 µg/$590
ARG1 / Arginase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.6 kDa
100 µg/$494
ARG1 / Arginase 1 Protein - Human arginase I catalyzes the hydrolysis of L-arginine to form urea.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 329 amino acid recombinant protein has a predicted molecular mass of approximately 36 kD. The DTT-reduced and non-reduced protein migrates at approximately 40 kD by SDS-PAGE. The predicted N-terminal amino acid is Met.
10 µg/$355; 25 µg/$497; 100 µg/$1,186; 500 µg/$3,043
ARG1 / Arginase 1 Protein - Active Arginase (ARG) by WB
Select
E. coli
His, N-Terminal
37kDa
10 µg/$314; 50 µg/$650; 200 µg/$1,225; 100 µg/$1,030; 1 mg/$2,465; 500 µg/$1,966; 5 mg/$4,537; 2 mg/$2,657
ARG1 / Arginase 1 Protein - Active Arginase (ARG) by WB
Select
E. coli
His, N-Terminal
37kDa
10 µg/$331; 50 µg/$752; 200 µg/$1,367; 100 µg/$1,158; 1 mg/$2,650; 500 µg/$2,147; 5 mg/$5,265; 2 mg/$2,841
ARG1 / Arginase 1 Protein
Select
E. coli
His-SUMO
50.79 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
ARG1 / Arginase 1 Protein - 12.5% SDS-PAGE of human ARG1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
61.1 kDa
10 µg/$479; 25 µg/$670
ARG1 / Arginase 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
36.2 kDa
100 µg/$1,214
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.6 kDa
10 µg/$429; 50 µg/$805
Select
E. coli
None
~34 kDa
10 µg/$386
Viewing 1-24 of 24 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).