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ARH / LDLRAP1
low density lipoprotein receptor adaptor protein 1
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
| Gene Name: | low density lipoprotein receptor adaptor protein 1 |
| Synonyms: | LDLRAP1, ARH, ARH1, FHCB1, FHCB2, LDL receptor adaptor protein, ARH2 |
| Target Sequences: | NP_056442.2 Q5SW96 |
Publications (3)
1
Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. Molecular cancer research : MCR. 2015 13:1509-19. (WB; Human)
[Full Text Article]
[PubMed:26224368]
[PMC:PMC4644680]
Related Antibodies: LS-C20125.
2
SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Qun Chen , Fan Zhang , Lei Dong , Huimin Wu , Jie Xu , Hanqin Li , Jin Wang, Zhen Zhou, Chunyan Liu, Yanbo Wang, Yuyan Liu, Liangsheng Lu, Chen Wang, Minghui Liu, Xi Chen, Cheng Wang, Chunni Zhang, Dangsheng Li, Ke Zen, Fangyu Wang, Qipeng Zhang, Chen-Yu Zhang. Cell Research. 2020 August; [Full Text Article]
[PubMed:32801357]
[PMC:PMC8026584]
Related Antibodies: LS-C20125.
3
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q, Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K, Zhang CY. Cell Research. Jan;22:107-26. [Full Text Article]
[PubMed:21931358]
[PMC:PMC3351925]
Related Antibodies: LS-C20125.
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ARH / LDLRAP1 Goat anti-Human Polyclonal (aa2-14) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Human, Monkey
IF, Peptide-ELISA
Unconjugated
100 µg/$503
ARH / LDLRAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI7E11) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI7E11) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (4G4-D5) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
ARH / LDLRAP1 Rabbit anti-Human Polyclonal (aa59-308) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
ARH / LDLRAP1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
ARH / LDLRAP1 Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
WB
Unconjugated
100 µl/$424
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI4B10) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4B10) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI2B2) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2B2) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI3H10) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3H10) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI5A12) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5A12) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI7H10) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI7H10) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI4G5) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4G5) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Mouse anti-Human Monoclonal (OTI7G2) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
ARH / LDLRAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI7G2) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
ARH / LDLRAP1 Rabbit anti-Human Polyclonal (aa11-42) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ARH / LDLRAP1 Rabbit anti-Human Polyclonal (aa277-306) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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