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ARH / LDLRAP1

low density lipoprotein receptor adaptor protein 1

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

Gene Name: low density lipoprotein receptor adaptor protein 1
Synonyms: LDLRAP1, ARH, ARH1, FHCB1, FHCB2, LDL receptor adaptor protein, ARH2
Target Sequences: NP_056442.2 Q5SW96

Publications (3)

1
Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. Molecular cancer research : MCR. 2015 13:1509-19. (WB; Human) [Full Text Article] [PubMed:26224368] [PMC:PMC4644680] Related Antibodies: LS-C20125.
2
SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Qun Chen , Fan Zhang , Lei Dong , Huimin Wu , Jie Xu , Hanqin Li , Jin Wang, Zhen Zhou, Chunyan Liu, Yanbo Wang, Yuyan Liu, Liangsheng Lu, Chen Wang, Minghui Liu, Xi Chen, Cheng Wang, Chunni Zhang, Dangsheng Li, Ke Zen, Fangyu Wang, Qipeng Zhang, Chen-Yu Zhang. Cell Research. 2020 August; [Full Text Article] [PubMed:32801357] [PMC:PMC8026584] Related Antibodies: LS-C20125.
3
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q, Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K, Zhang CY. Cell Research. Jan;22:107-26. [Full Text Article] [PubMed:21931358] [PMC:PMC3351925] Related Antibodies: LS-C20125.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
ARH / LDLRAP1 (6)
No (6)
GST (1)
His (2)
Myc-DDK (Flag) (3)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
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ARH / LDLRAP1 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
ARH / LDLRAP1 Protein - Recombinant Low Density LiPoprotein Receptor Adaptor Protein 1 By SDS-PAGE
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E. coli
His
37.7 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
ARH / LDLRAP1 Protein - Purified recombinant protein LDLRAP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
33.7 kDa
20 µg/$1,107
ARH / LDLRAP1 Protein - 12.5% SDS-PAGE of human LDLRAP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.67 kDa
10 µg/$479; 25 µg/$670
ARH / LDLRAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.7 kDa
20 µg/$150
ARH / LDLRAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.7 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).