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Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | Rho GTPase activating protein 26 |
Synonyms: | ARHGAP26, GRAF, KIAA0621, GRAF1, OPHN1L, Oligophrenin-1-like protein, OPHN1L1 |
Target Sequences: | NM_015071 NP_055886.1 Q9UNA1 |
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