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ARHGEF10 / GEF10 is a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants.
Gene Name: | Rho guanine nucleotide exchange factor (GEF) 10 |
Synonyms: | ARHGEF10, GEF10, KIAA0294 |
Target Sequences: | NM_014629 NP_055444.2 O15013 |
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