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ARHGEF25 / GEFT
Rho guanine nucleotide exchange factor (GEF) 25
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.
| Gene Name: | Rho guanine nucleotide exchange factor (GEF) 25 |
| Synonyms: | ARHGEF25, GEFT, RhoA/RAC/CDC42 exchange factor, p63RhoGEF, RAC/CDC42 exchange factor |
| Target Sequences: | AA463333 Q86VW2 Q86VW2 |
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