ARHGEF4

Rho guanine nucleotide exchange factor (GEF) 4

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

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Products

Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

ARHGEF4 (6)

Publications

No (6)

Tag

GST, N-terminus (2)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

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Human ARHGEF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90102

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.2 kDa

Price:

20 µg/$215

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Human ARHGEF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90101

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.9 kDa

Price:

20 µg/$215

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ARHGEF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108494

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.2 kDa

Price:

100 µg/$710

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ARHGEF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101305

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.9 kDa

Price:

100 µg/$710

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Human ARHGEF4 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G62377

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ARHGEF4 Protein (Recombinant GST, N-terminus) (aa581-690) - LS-G62375

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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