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Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Gene Name: | Rho guanine nucleotide exchange factor (GEF) 7 |
Synonyms: | ARHGEF7, COOL1, COOL-1, Hypothetical protein kiaa0142, Nbla10314, p85, p85COOL1, p85SPR, PIXB, KIAA0142, p50, PAK3BP, BETA-PIX, p50BP |
Target Sequences: | NM_003899 NP_003890.1 Q14155 |
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