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Shirley, MA 01464
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20700 44th Avenue W
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ARID4B
AT rich interactive domain 4B (RBP1-like)
ARID4B is a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.
| Gene Name: | AT rich interactive domain 4B (RBP1-like) |
| Synonyms: | ARID4B, BRCAA1, SIN3A-associated protein 180, BCAA, Rb-binding protein homolog, RBBP1L1, RBP1L1, SAP180 |
| Target Sequences: | NM_016374 NP_057458.4 Q4LE39 |
Publications (1)
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