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Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.
Gene Name: | ring finger protein 111 |
Synonyms: | RNF111, Arkadia, ARK, Ring finger protein 111, DKFZP761D081 |
Target Sequences: | NM_017610 NP_060080.6 Q6ZNA4 |
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