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ARL6

ADP-ribosylation factor-like 6

Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.

Gene Name: ADP-ribosylation factor-like 6
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARL6, ADP-ribosylation factor-like 6, BBS3, RP55
Target Sequences: NM_032146 NP_115522.1 Q9H0F7

Publications (1)

1
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR. The Journal of biological chemistry. 2010 285:16218-30. [PubMed:20207729] [PMC:PMC2871489]

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
ARL6 (9)
No (9)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (6)
Human (7)
293T Cells (2)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (3)
ARL6 Protein - 12.5% SDS-PAGE of human ARL6 stained with Coomassie Blue
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Wheat Germ Extract
GST
46.2 kDa
2 µg/$439
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
ARL6 Protein - Purified recombinant protein ARL6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
ARL6 Protein - Purified recombinant protein ARL6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
ARL6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
ARL6 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ARL6 Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).